Nurse Practitioner - First 7-day H. pylori treatment approved
FAST H. PYLORI REGIMEN
Rabeprazole sodium (Aciphex) is now approved in combination with antibiotics to treat Helicobacter pylori infection in 7 days. Current treatments for H. pylori infection take 10-14 days.
In combination with amoxicillin and clarithromycin (Biaxin) as a threedrug regimen, rabeprazole is indicated for the treatment of H. pylori infection and duodenal ulcer disease (active or history within the last 5 years) to eradicate H. pylori.
The 1-week treatment regimen was tested in a multicenter, double blind, placebo-controlled trial of 803 patients infected with H. pylori. Eighty-three percent of patients treated with rabeprazole, amoxicillin, and clarithromycin (RAC) taken twice daily were free of H. pylori after 7 days of therapy.
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No adverse events unique to this drug combination were observed in clinical trials. The most frequently reported drug-related adverse events in RAC trials were diarrhea and taste perversion. For full prescribing information, consult product labeling.
Rabeprazole is a product of Eisai Inc. and is co-promoted by Janssen Pharmaceutica.
Copyright Springhouse Corporation Jan 2003
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